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KMID : 0385920080190010082
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Journal of the Korean Society of Emergency Medicine
2008 Volume.19 No. 1 p.82 ~ p.87
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S-100B Protein as a Useful Serologic Marker of Acute Stroke with Nonspecific Neurologic Symptoms
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Park Maeng-Real
Ahn Ji-Yoon
Oh Bum-Jin
Kim Won
Lim Kyoung-Soo
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Abstract
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Purpose: There is a distinct probability of severe complications with stroke unless patients are administered proper treatment at the optimal time. S-100B protein has been reported to be elevated in brain injuries. The current study
investigates the efficacy of serum S-100B protein administration during the diagnostic process for patients who have
had an acute stroke.
Methods: We prospectively recruited the patients with nonspecific neurological symptoms. Non-specific neurological symptoms were defined as no focal neurological deficits or stroke suspected symptoms with NIHSS score zero. We grouped the patients according to the presence of a brain lesion (positive vs negative group) by computed tomography or magnetic resonance imaging. Using serum S-100B protein together with CT/MRI imaging at the time of diagnosis, the cutoff value, sensitivities, and specificities were calculated in making a diagnosis of acute stroke.
Results: Thirty one patients were enrolled. The level of serum S-100B protein was higher in positive group (median 0.201, interquartile range 0.134-0.469) than in negative group (0.085, 0.060-0.106, p=0.001). In diagnosing acute
stroke, the sensitivity was 90.9% at a cutoff value for serum S-100B protein of 0.10 μg/L . At the cutoff level of serum S-
100B protein and the specificity was 75.0%.
Conclusion: The current results suggest that serum S-100B protein may be a useful serologic marker for detecting acute stroke that is suspected with non-specific neurological abnormalities. Further studies are necessary to use the marker as a screening method for acute strokes.
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KEYWORD
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S-100B protein, Stroke, Neurologic deficits, Serologic Tests, Diagnosis
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